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Proceedings Paper

Three-dimensional photoacoustic imaging with a clinical two-dimensional matrix ultrasound transducer
Author(s): Todd N. Erpelding; Yu Wang; Ladislav Jankovic; Zijian Guo; Jean-Luc Robert; Guillaume David; Chulhong Kim; Lihong V. Wang
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Paper Abstract

Photoacoustic tomography provides both structural and functional imaging in vivo based on optical absorption contrast. A novel imaging system that incorporates a two-dimensional matrix ultrasound probe for combined photoacoustic and ultrasonic three-dimensional (3D) volumetric imaging is presented. The system consists of a tunable dye laser pumped by a Nd:YAG laser, a commercial ultrasound imaging system (Philips iU22) with a two-dimensional matrix transducer (Philips X7-2, 2500 elements, 2-7 MHz), and a multichannel data acquisition system which allows us to acquire RF channel data. Compared with alternative 3D techniques, this system is attractive because it can generate co-registered 3D photoacoustic and ultrasound images without mechanical scanning. Moreover, the lateral resolution along the azimuth and elevational directions are measured to be 0.77 ± 0.06 mm and 0.96 ± 0.06 mm, respectively, based on reconstructed photoacoustic images of phantoms containing individual human hairs. Finally, in vivo 3D photoacoustic sentinel lymph node mapping using methylene blue dye in a rat model is demonstrated.

Paper Details

Date Published: 18 February 2011
PDF: 6 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990A (18 February 2011); doi: 10.1117/12.875169
Show Author Affiliations
Todd N. Erpelding, Philips Research North America (United States)
Yu Wang, Washington Univ. in St. Louis (United States)
Ladislav Jankovic, Philips Research North America (United States)
Zijian Guo, Washington Univ. in St. Louis (United States)
Jean-Luc Robert, Philips Research North America (United States)
Guillaume David, Philips Research North America (United States)
Chulhong Kim, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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