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Proceedings Paper

Folate receptor targeted Type 1 photosensitizer bioconjugates for tumor visualization and phototherapy
Author(s): Raghavan Rajagopalan; Amruta R. Poreddy; Amolkumar Karwa; Bethel Asmelash; Nicole E. Putnam; Lori Chinen; Maureen Nichols; J. Jeng Shieh; Richard B. Dorshow
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Paper Abstract

Folate receptors are over expressed in many types of cancers, including, ovarian, breast, and cervical. In our continuing efforts toward the development of targeted Type 1 phototherapeutic agents, an azide-based Type 1 photosensitizer and a pyrzine-based fluorophore that absorb and emits in the visible region, and a dual diagnostic-therapeutic probe consisting of the fluorophore and the photosensitizer were prepared and independently conjugated to two folate receptor specific vectors: γ-carboxyl-modified folic acid and anti-human FOLR1 (folate receptor-1) antibody In vitro receptor binding study showed that all the conjugates had high (ca 1-7 nM) affinity to the folate receptor. Confocal microscopy images indicated that the pyrazine conjugates were selectively taken up by the folate receptor expressing ovarian cancer KB cells.

Paper Details

Date Published: 8 February 2011
PDF: 7 pages
Proc. SPIE 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, 78860D (8 February 2011); doi: 10.1117/12.875166
Show Author Affiliations
Raghavan Rajagopalan, Covidien Pharmaceuticals (United States)
Amruta R. Poreddy, Covidien Pharmaceuticals (United States)
Amolkumar Karwa, Covidien Pharmaceuticals (United States)
Bethel Asmelash, Covidien Pharmaceuticals (United States)
Nicole E. Putnam, Covidien Pharmaceuticals (United States)
Lori Chinen, Covidien Pharmaceuticals (United States)
Maureen Nichols, Covidien Pharmaceuticals (United States)
J. Jeng Shieh, Covidien Pharmaceuticals (United States)
Richard B. Dorshow, Covidien Pharmaceuticals (United States)

Published in SPIE Proceedings Vol. 7886:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX
David H. Kessel; Tayyaba Hasan, Editor(s)

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