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Proceedings Paper

A novel optical probe for pH sensing in gastro-esophageal apparatus
Author(s): F. Baldini; G. Ghini; A. Giannetti; F. Senesi; C. Trono
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Paper Abstract

Monitoring gastric pH for long periods, usually 24 h, may be essential in analyzing the physiological pattern of acidity, in obtaining information on changes in activity during peptic ulcer disease, and in assessing the effect of antisecretory drugs. Gastro-esophageal reflux, which causes a pH decrease in the esophagus content from pH 7 even down to pH 2, can determine esophagitis with possible strictures and Barrett's esophagus. One of the difficulties of the optical measurement of pH in the gastro-esophageal apparatus lies in the required extended working range from 1 to 8 pH units. The present paper deals with a novel optical pH sensor, using methyl red as optical pH indicator. Contrary to all acidbase indicators characterized by working ranges limited to 2-3 pH units, methyl red, after its covalent immobilization on controlled pore glass (CPG), is characterized by a wide working range which fits with the clinical requirements. The novel probe design here described is suitable for gastro-esophageal applications and allows the optimization of the performances of the CPG with the immobilised indicator. This leads to a very simple configuration characterized by a very fast response time.

Paper Details

Date Published: 22 February 2011
PDF: 6 pages
Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 78901J (22 February 2011); doi: 10.1117/12.875101
Show Author Affiliations
F. Baldini, Istituto di Fisica Applicata Nello Carrara (Italy)
G. Ghini, Istituto di Fisica Applicata Nello Carrara (Italy)
A. Giannetti, Istituto di Fisica Applicata Nello Carrara (Italy)
F. Senesi, Istituto di Fisica Applicata Nello Carrara (Italy)
C. Trono, Istituto di Fisica Applicata Nello Carrara (Italy)


Published in SPIE Proceedings Vol. 7890:
Advanced Biomedical and Clinical Diagnostic Systems IX
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest, Editor(s)

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