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Proceedings Paper

In utero mouse embryonic imaging with OCT for ophthalmologic research
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Paper Abstract

Live imaging of an eye during embryonic development in mammalian model is important for understanding dynamic aspects of normal and abnormal eye morphogenesis. In this study, we used Swept Source Optical Coherence Tomography (SS-OCT) for live structural imaging of mouse embryonic eye through the uterine wall. The eye structure was reconstructed in mouse embryos at 13.5 to 17.5 days post coitus (dpc). Despite the limited imaging depth of OCT in turbid tissues, we were able to visualize the whole eye globe at these stages. These results suggest that live in utero OCT imaging is a useful tool to study embryonic eye development in the mouse model.

Paper Details

Date Published: 11 February 2011
PDF: 4 pages
Proc. SPIE 7885, Ophthalmic Technologies XXI, 788508 (11 February 2011); doi: 10.1117/12.875075
Show Author Affiliations
Saba H. Syed, Univ. of Houston (United States)
Irina V. Larina, Baylor College of Medicine (United States)
Mary E. Dickinson, Baylor College of Medicine (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)
Saratov State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 7885:
Ophthalmic Technologies XXI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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