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Proceedings Paper

Modeling of PDT kinetics in cell killing
Author(s): Ioannis Gkigkitzis; Chunmei Yang; Yuanming Feng; Jun Q. Lu; Xin-Hua Hu
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Paper Abstract

Photodynamic therapy (PDT) provides an effective option for treatment of tumors and other diseases. In this work, we extended a previous rate-equation model in time domain with consideration of oxygen diffusion in a spherical cell model. Enhanced oxygen diffusion through cell membrane and non-PDT uptake of oxygen inside the cell have been investigated to study their effect on photobleaching and oxidization leading to cell killing within the context of PDT. We found that the improved PDT model can take into the account of the Michaelis-Menten uptake of the oxygen in addition to diffusion which allows quantitative modeling of photobleaching and cell killing.

Paper Details

Date Published: 11 February 2011
PDF: 6 pages
Proc. SPIE 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, 78860O (11 February 2011); doi: 10.1117/12.875066
Show Author Affiliations
Ioannis Gkigkitzis, East Carolina Univ. (United States)
Chunmei Yang, Tianjin Univ. (China)
Yuanming Feng, Tianjin Univ. (China)
Jun Q. Lu, East Carolina Univ. (United States)
Xin-Hua Hu, East Carolina Univ. (United States)


Published in SPIE Proceedings Vol. 7886:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX
David H. Kessel; Tayyaba Hasan, Editor(s)

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