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Proceedings Paper

Phase characterization of oscillatory components of the cerebral concentrations of oxy-hemoglobin and deoxy-hemoglobin
Author(s): Michele Pierro; Angelo Sassaroli; Feng Zheng; Sergio Fantini
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Paper Abstract

We present a study of the relative phase of oscillations of cerebral oxy- and deoxy-hemoglobin concentrations in the low-frequency range, namely 0.04-0.12 Hz. We have characterized the potential contributions of noise to the measured phase distributions, and we have performed phase measurements on the brain of a human subject at rest, and on the brain of a human subject during stage I sleep. While phase distributions of pseudo hemodynamic oscillations generated from noise (obtained by applying to two independent sets of random numbers the same linear transformation that converts absorption coefficients at 690 and 830 nm into concentrations of oxy- and deoxy-hemoglobin) are peaked at 180º, those associated with real hemodynamic changes can be peaked around any value depending on the underlying physiology and hemodynamics. In particular, preliminary results reported here indicate a greater phase lead of deoxy-hemoglobin vs. oxy-hemoglobin low-frequency oscillations during stage I sleep (82º ± 55º) than while the subject is awake (19º ± 58º).

Paper Details

Date Published: 17 February 2011
PDF: 7 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78960G (17 February 2011); doi: 10.1117/12.875010
Show Author Affiliations
Michele Pierro, Tufts Univ. (United States)
Angelo Sassaroli, Tufts Univ. (United States)
Feng Zheng, Tufts Univ. (United States)
Sergio Fantini, Tufts Univ. (United States)


Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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