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Proceedings Paper

Intrinsic optical signal imaging of glucose-stimulated physiological responses in the insulin secreting INS-1 β-cell line
Author(s): Yi-Chao Li; Wan-Xing Cui; Xu-Jing Wang; Franklin Amthor; Xin-Cheng Yao
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Paper Abstract

Intrinsic optical signal (IOS) imaging has been established for noninvasive monitoring of stimulus-evoked physiological responses in the retina and other neural tissues. Recently, we extended the IOS imaging technology for functional evaluation of insulin secreting INS-1 cells. INS-1 cells provide a popular model for investigating β-cell dysfunction and diabetes. Our experiments indicate that IOS imaging allows simultaneous monitoring of glucose-stimulated physiological responses in multiple cells with high spatial (sub-cellular) and temporal (sub-second) resolution. Rapid image sequences reveal transient optical responses that have time courses comparable to glucose-evoked β-cell electrical activities.

Paper Details

Date Published: 11 February 2011
PDF: 6 pages
Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 79070Y (11 February 2011); doi: 10.1117/12.874989
Show Author Affiliations
Yi-Chao Li, The Univ. of Alabama at Birmingham (United States)
Wan-Xing Cui, The Univ. of Alabama at Birmingham (United States)
Xu-Jing Wang, The Univ. of Alabama at Birmingham (United States)
Franklin Amthor, The Univ. of Alabama at Birmingham (United States)
Xin-Cheng Yao, The Univ. of Alabama at Birmingham (United States)


Published in SPIE Proceedings Vol. 7907:
Biomedical Applications of Light Scattering V
Adam P. Wax; Vadim Backman, Editor(s)

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