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Proceedings Paper

Photoacoustic image-guided needle biopsy of sentinel lymph nodes
Author(s): Chulhong Kim; Todd N. Erpelding; Walter J. Akers; Konstantin Maslov; Liang Song; Ladislav Jankovic; Julie A. Margenthaler; Samuel Achilefu; Lihong V. Wang
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Paper Abstract

We have implemented a hand-held photoacoustic and ultrasound probe for image-guided needle biopsy using a modified clinical ultrasound array system. Pulsed laser light was delivered via bifurcated optical fiber bundles integrated with the hand-held ultrasound probe. We photoacoustically guided needle insertion into rat sentinel lymph nodes (SLNs) following accumulation of indocyanine green (ICG). Strong photoacoustic image contrast of the needle was achieved. After intradermal injection of ICG in the left forepaw, deeply positioned SLNs (beneath 2-cm thick chicken breast) were easily indentified in vivo and in real time. Further, we confirmed ICG uptake in axillary lymph nodes with in vivo and ex vivo fluorescence imaging. These results demonstrate the clinical potential of this hand-held photoacoustic system for facile identification and needle biopsy of SLNs for cancer staging and metastasis detection in humans.

Paper Details

Date Published: 18 February 2011
PDF: 5 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990K (18 February 2011); doi: 10.1117/12.874956
Show Author Affiliations
Chulhong Kim, Washington Univ. in St. Louis (United States)
Todd N. Erpelding, Philips Research North America (United States)
Walter J. Akers, Washington Univ. School of Medicine (United States)
Konstantin Maslov, Washington Univ. in St. Louis (United States)
Liang Song, Washington Univ. in St. Louis (United States)
Ladislav Jankovic, Philips Research North America (United States)
Julie A. Margenthaler, Washington Univ. School of Medicine (United States)
Samuel Achilefu, Washington Univ. School of Medicine (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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