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Proceedings Paper

Radiofrequency circuit design and performance evaluation for small animal frequency-domain NIR fluorescence optical tomography
Author(s): Chinmay Darne; Banghe Zhu; Yujie Lu; I-Chih Tan; John Rasmussen; Eva M. Sevick-Muraca
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Paper Abstract

Herein we report on hardware development and evaluation for frequency-domain photon migration (FDPM) technique that is miniaturized for incorporation into a micro-CT gantry for hybrid CT/NIR/PET imaging. Immunity to endogenous optical properties and enhanced contrast associated with fluorophore lifetime is inherent to the FDPM measurements and enables unique opportunities for quantitative tomography when compared to the time independent (continuous wave) approach. A miniaturized radiofrequency (rf) circuitry has been developed in our laboratory for homodyne FDPM measurements that makes use of a single 100MHz oscillator to simultaneously launch optically modulated excitation light into a small animal as well as to modulate an NIR sensitive image intensifier for collection of fluorescent signals. The use of a single oscillator not only eliminates signal drift that otherwise results from the use of multiple oscillators individually driving both source and detector, but also reduces the circuit footprint for incorporation into the CT gantry. Herein, overall system performance parameters of signal-to-noise ratio, measurement precision, spatial resolution, modulation depth (ac/dc), excitation light rejection, and clinically relevant data acquisition times are presented for mouse phantom data. Image reconstruction of phantom data and integration of circuitry for hybrid CT/NIR/PET imaging is also presented towards the ultimate validation of NIR optical tomography using PET imaging as a "gold-standard" for quantification.

Paper Details

Date Published: 17 February 2011
PDF: 6 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 789621 (17 February 2011); doi: 10.1117/12.874946
Show Author Affiliations
Chinmay Darne, Brown Foundation Institute of Molecular Medicine, The Univ. of Texas Health Science Ctr. at Houston (United States)
Banghe Zhu, Brown Foundation Institute of Molecular Medicine, The Univ. of Texas Health Science Ctr. at Houston (United States)
Yujie Lu, Brown Foundation Institute of Molecular Medicine, The Univ. of Texas Health Science Ctr. at Houston (United States)
I-Chih Tan, Brown Foundation Institute of Molecular Medicine, The Univ. of Texas Health Science Ctr. at Houston (United States)
John Rasmussen, Brown Foundation Institute of Molecular Medicine, The Univ. of Texas Health Science Ctr. at Houston (United States)
Eva M. Sevick-Muraca, Brown Foundation Institute of Molecular Medicine, The Univ. of Texas Health Science Ctr. at Houston (United States)


Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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