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Proceedings Paper

Exploring the mechanism of radiation-enhanced hepatocellular carcinoma cell invasion by swept-source optical coherence tomography
Author(s): W. C. Kuo; W. W. Cheng; C. H. Chou; J.C.-H. Cheng
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Paper Abstract

Ionizing radiation is a standard treatment for various human solid tumors. However, several clinical studies showed that a significant proportion of patients undergoing radiotherapy for hepatocellular carcinoma (HCC) develop intrahepatic and extrahepatic metastasis. Understanding of radiation-induced cancer cell invasiveness and behavior is essential and of great important for developing suitable treatment strategies to contain cancer spread. Therefore, in this study we evaluated the effectiveness of using swept source optical coherence tomography (SS-OCT) to monitor the enhancement of HCC cell invasiveness by radiation. SS-OCT images were acquired and recorded to obtain three-dimensional data sets per four hours in 48 hours after irradiating HepG2 cells with 7.5 Gy. The cell migration behavior in three-dimensional tissue models was quantified from images of radiation-induced and sham-irradiated cells.

Paper Details

Date Published: 11 February 2011
PDF: 6 pages
Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 78890S (11 February 2011); doi: 10.1117/12.874944
Show Author Affiliations
W. C. Kuo, National Taiwan Normal Univ. (Taiwan)
W. W. Cheng, National Taiwan Normal Univ. (Taiwan)
C. H. Chou, National Taiwan Univ. Hospital (Taiwan)
J.C.-H. Cheng, National Taiwan Univ. Hospital (Taiwan)
National Taiwan Univ. College of Medicine (Taiwan)

Published in SPIE Proceedings Vol. 7889:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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