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Proceedings Paper

A sample-in result-out lab-on-a-chip device: from prototype to mass fabrication
Author(s): Richard Klemm; Nadine Hlawatsch; Claudia Gärtner; Mathieu Jung; Julian Höth; Ciara O'Sullivan; Holger Becker
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Paper Abstract

In this paper we demonstrate the development of an integrated lab-on-a-chip system for the point-of-care diagnostics of Coeliac disease. A two-step approach is used, using two different microfluidic chips with identical footprint and functional landscape, one for the analysis of the genetic predisposition using human leukocyte antigen typing, the second for a serology assay. Emphasis has been put on using a seamless technology path from prototyping to final device manufacture in order to allow an upscaling of production volumes without a chance in production technology. Therefore, injection molding has been extensively used, however using standard formats allowing the use of family tools in order to reduce the cost of manufacturing.

Paper Details

Date Published: 14 February 2011
PDF: 5 pages
Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 79290D (14 February 2011); doi: 10.1117/12.874907
Show Author Affiliations
Richard Klemm, microfluidic ChipShop GmbH (Germany)
Nadine Hlawatsch, microfluidic ChipShop GmbH (Germany)
Claudia Gärtner, microfluidic ChipShop GmbH (Germany)
Mathieu Jung, Institut für Mikrotechnik Mainz GmbH (Germany)
Julian Höth, Institut für Mikrotechnik Mainz GmbH (Germany)
Ciara O'Sullivan, Univ. Rovira i Virgili (Spain)
Holger Becker, microfluidic ChipShop GmbH (Germany)

Published in SPIE Proceedings Vol. 7929:
Microfluidics, BioMEMS, and Medical Microsystems IX
Holger Becker; Bonnie L. Gray, Editor(s)

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