Share Email Print
cover

Proceedings Paper

Studying skin penetration by NMR imaging
Author(s): J. M. Burg; M. Voelker; P. Schlupp; T. Schmidts; U. Maeder; T. Bergmann; F. Runkel; J. T. Heverhagen; M. Fiebich
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Skin penetration studies are an important part for the development of dermal drug carrier systems. As a novel approach a 7-tesla Magnetic Resonance Imaging (MRI) Scanner was used to obtain information about the penetration of agents into the skin. The main advantage of this method is, that the properties of the skin does not influence the signals. Compared to optical assessments the MRI method is not limited to imaging depth. Furthermore, it is possible to analyze fat and water components of the skin separately. The aim of this work was to evaluate, if this method is a promising analysis tool for the visualization of the transport of substances across the skin. Gadobutrol (Gadovist®1.0), respresenting a coventional contrast agent in MRI, was used as a model drug for the visualization of the skin penetration. These first promising results showed that Gadobutrol, incorporated in an oil-in-water emulsion, could be detected across the skin tissue compared to an aqueous solution. After 24 hours, the pixel intensity value was increased about 4-fold compared to an untreated tissue.

Paper Details

Date Published: 10 February 2011
PDF: 4 pages
Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920V (10 February 2011); doi: 10.1117/12.874886
Show Author Affiliations
J. M. Burg, Univ. of Applied Sciences Giessen-Friedberg (Germany)
M. Voelker, Philipps Univ. Marburg (Germany)
P. Schlupp, Univ. of Applied Sciences Giessen-Friedberg (Germany)
T. Schmidts, Univ. of Applied Sciences Giessen-Friedberg (Germany)
U. Maeder, Univ. of Applied Sciences Giessen-Friedberg (Germany)
T. Bergmann, Univ. of Applied Sciences Giessen-Friedberg (Germany)
F. Runkel, Univ. of Applied Sciences Giessen-Friedberg (Germany)
J. T. Heverhagen, Philipps Univ. Marburg (Germany)
M. Fiebich, Univ. of Applied Sciences Giessen-Friedberg (Germany)


Published in SPIE Proceedings Vol. 7892:
Multimodal Biomedical Imaging VI
Fred S. Azar; Xavier Intes, Editor(s)

© SPIE. Terms of Use
Back to Top