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Proceedings Paper

Photobiomodulatory effects of He-Ne laser on excision wounds
Author(s): Vijendra Prabhu; Satish B. S. Rao; Pramod Kumar; Lakshmi Rao; Krishna K. Mahato
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Paper Abstract

Presently, great importance has been given to Low Level Laser Therapy (LLLT) with the intent of promoting wound healing process. The present study was aimed to investigate the promotive effect of LLLT on full thickness excision wounds in Swiss albino mice using optical fiber probe based light device. Circular wounds of diameter 15 mm were illuminated with single exposure of various laser doses 1, 2, 3, 4, 6, 8 and 10 J/cm2 along with appropriate controls. Further, an optimal dose of 2 J/cm2 was applied to excision wounds at different post-wounding treatment schedules (0, 24 h and 48 h) to explicate the relations between treatment schedule and its tissue regeneration potential. Wound area, mean wound healing time along with hydroxyproline and glucosamine levels from wound ground tissue was assessed to evaluate the resultant photobiostimulatory outcome. Histological analysis was performed on day 10 of post-wounding. A significant increase in hydroxyproline (P< 0.001) and glucosamine levels (P< 0.01) were observed in 2 J/cm2 irradiation group, which was also substantiated by histological findings. In conclusion, the present study demonstrated that the immediate irradiation of 2 J/cm2 dose following wounding hasten the healing process compared to the unilluminated control.

Paper Details

Date Published: 17 February 2011
PDF: 9 pages
Proc. SPIE 7887, Mechanisms for Low-Light Therapy VI, 78870H (17 February 2011); doi: 10.1117/12.874814
Show Author Affiliations
Vijendra Prabhu, Manipal Univ. (India)
Satish B. S. Rao, Manipal Univ. (India)
Pramod Kumar, Manipal Univ. (India)
Lakshmi Rao, Manipal Univ. (India)
Krishna K. Mahato, Manipal Univ. (India)


Published in SPIE Proceedings Vol. 7887:
Mechanisms for Low-Light Therapy VI
Michael R. Hamblin; Ronald W. Waynant; Juanita Anders, Editor(s)

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