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Proceedings Paper

Imaging microscopic structures in pathological retinas using a flood-illumination adaptive optics retinal camera
Author(s): Clément Viard; Kiyoko Nakashima; Barbara Lamory; Michel Pâques; Xavier Levecq; Nicolas Château
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Paper Abstract

This research is aimed at characterizing in vivo differences between healthy and pathological retinal tissues at the microscopic scale using a compact adaptive optics (AO) retinal camera. Tests were performed in 120 healthy eyes and 180 eyes suffering from 19 different pathological conditions, including age-related maculopathy (ARM), glaucoma and rare diseases such as inherited retinal dystrophies. Each patient was first examined using SD-OCT and infrared SLO. Retinal areas of 4°x4° were imaged using an AO flood-illumination retinal camera based on a large-stroke deformable mirror. Contrast was finally enhanced by registering and averaging rough images using classical algorithms. Cellular-resolution images could be obtained in most cases. In ARM, AO images revealed granular contents in drusen, which were invisible in SLO or OCT images, and allowed the observation of the cone mosaic between drusen. In glaucoma cases, visual field was correlated to changes in cone visibility. In inherited retinal dystrophies, AO helped to evaluate cone loss across the retina. Other microstructures, slightly larger in size than cones, were also visible in several retinas. AO provided potentially useful diagnostic and prognostic information in various diseases. In addition to cones, other microscopic structures revealed by AO images may also be of interest in monitoring retinal diseases.

Paper Details

Date Published: 11 February 2011
PDF: 10 pages
Proc. SPIE 7885, Ophthalmic Technologies XXI, 788509 (11 February 2011); doi: 10.1117/12.874766
Show Author Affiliations
Clément Viard, Imagine Eyes (France)
Kiyoko Nakashima, CHNO Quinze-Vingts (France)
Barbara Lamory, Imagine Eyes (France)
Michel Pâques, CHNO Quinze-Vingts (France)
Xavier Levecq, Imagine Eyes (France)
Nicolas Château, Imagine Eyes (France)

Published in SPIE Proceedings Vol. 7885:
Ophthalmic Technologies XXI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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