Share Email Print
cover

Proceedings Paper

In vivo swine myocardial tissue characterization and monitoring during open chest surgery by time-resolved diffuse near-infrared spectroscopy
Author(s): Lorenzo Spinelli; Davide Contini; Andrea Farina; Alessandro Torricelli; Antonio Pifferi; Rinaldo Cubeddu; Luca Ascari; Luca Potì; Maria Giovanna Trivella; Antonio L'Abbate; Stefano Puzzuoli
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Cardiovascular diseases are the main cause of death in industrialized countries. Worldwide, a large number of patients suffering from cardiac diseases are treated by surgery. Despite the advances achieved in the last decades with myocardial protection, surgical failure can still occur. This is due at least in part to the imperfect control of the metabolic status of the heart in the various phases of surgical intervention. At present, this is indirectly controlled by the electrocardiogram and the echographic monitoring of cardiac mechanics as direct measurements are lacking. Diffuse optical technologies have recently emerged as promising tools for the characterization of biological tissues like breast, muscles and bone, and for the monitoring of important metabolic parameters such as blood oxygenation, volume and flow. As a matter of fact, their utility has been demonstrated in a variety of applications for functional imaging of the brain, optical mammography and monitoring of muscle metabolism. However, due to technological and practical difficulties, their potential for cardiac monitoring has not yet been exploited. In this work we show the feasibility of the in-vivo determination of absorption and scattering spectra of the cardiac muscle in the 600-1100 nm range, and of monitoring myocardial tissue hemodynamics by time domain near-infrared spectroscopy at 690 nm and 830 nm. Both measurements have been performed on the exposed beating heart during open chest surgery in pigs, an experimental model closely mimicking the clinical cardio-surgical setting.

Paper Details

Date Published: 17 February 2011
PDF: 7 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78833D (17 February 2011); doi: 10.1117/12.874697
Show Author Affiliations
Lorenzo Spinelli, CNR, Istituto di Fotonica e Nanotecnologie (Italy)
Davide Contini, Politecnico di Milano (Italy)
Andrea Farina, Politecnico di Milano (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Antonio Pifferi, CNR, Istituto di Fotonica e Nanotecnologie (Italy)
Politecnico di Milano (Italy)
Rinaldo Cubeddu, CNR, Istituto di Fotonica e Nanotecnologie (Italy)
Politecnico di Milano (Italy)
Luca Ascari, CEIICP, Scuola Superiore Sant'Anna (Italy)
Luca Potì, Consorzio Nazionale Interuniversitario per le Telecomunicazioni (Italy)
Maria Giovanna Trivella, CNR, Istituto di Fisiologia Clinica (Italy)
Antonio L'Abbate, CNR, Istituto di Fisiologia Clinica (Italy)
Scuola Superiore Sant'Anna (Italy)
Stefano Puzzuoli, CNR, Istituto di Fisiologia Clinica (Italy)
Scuola Superiore Sant'Anna (Italy)


Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong; Justus F. R. Ilgner; Bodo E. Knudsen; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

© SPIE. Terms of Use
Back to Top