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Proceedings Paper

Nanoscale nuclear architecture for cancer diagnosis by spatial-domain low-coherence quantitative phase microscopy
Author(s): Pin Wang; Rajan K. Bista; Walid E. Khalbuss; Wei Qiu; Kevin D. Staton; Lin Zhang; Teresa A. Brentnall; Randall E. Brand; Yang Liu
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Paper Abstract

Alterations in nuclear architecture are the hallmark diagnostic characteristic of cancer cells. In this work, we show that the nuclear architectural characteristics quantified by spatial-domain low-coherence quantitative phase microscopy (SL-QPM), is more sensitive for the identification of cancer cells than conventional cytopathology. We demonstrated the importance of nuclear architectural characteristics in both an animal model of intestinal carcinogenesis - APC/Min mouse model and human cytology specimens with colorectal cancer by identifying cancer from cytologically noncancerous appearing cells. The determination of nanoscale nuclear architecture using this simple and practical optical instrument is a significant advance towards cancer diagnosis.

Paper Details

Date Published: 12 February 2011
PDF: 9 pages
Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 790704 (12 February 2011); doi: 10.1117/12.874693
Show Author Affiliations
Pin Wang, Univ. of Pittsburgh (United States)
Rajan K. Bista, Univ. of Pittsburgh (United States)
Walid E. Khalbuss, Univ. of Pittsburgh Medical Ctr. Shadyside (United States)
Wei Qiu, Univ. of Pittsburgh Medical Ctr. Shadyside (United States)
Kevin D. Staton, Univ. of Pittsburgh (United States)
Lin Zhang, Univ. of Pittsburgh Cancer Institute (United States)
Teresa A. Brentnall, Univ. of Washington (United States)
Randall E. Brand, Univ. of Pittsburgh (United States)
Yang Liu, Univ. of Pittsburgh (United States)


Published in SPIE Proceedings Vol. 7907:
Biomedical Applications of Light Scattering V
Adam P. Wax; Vadim Backman, Editor(s)

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