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Proceedings Paper

DNA-RNA, DNA-DNA, DNA-protein and protein-protein interactions in diagnosis of skin cancers by FT-IR microspectroscopy
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Paper Abstract

Skin tissue infrared (IR) microspectroscopy may work as an optical diagnostic method for common skin cancer detection, progression, and specific characterization of carcinogenesis in skin tumours. Spectral results from BCC, SCC and MM skin samples demonstrated significant levels of the multiplet at about 1055 cm-1. Its activity level strongly correlated with the activity level of the most prominent peak in DNA/RNA triad in 5 BCC, in 3 SCC and only in 1 MM patient. DNA-RNA and DNA-DNA interactions as I965 < I1055 < Imax level DNA/RNA triad peak were the most clearly observed in 3 BCC patients with high-leveled peaks of nucleic acids, that were presented as I965 < I1055 > Imax level DNA/RNA triad peak in 3 SCC patients with the highest activity levels. Although mean values and the intensities of nucleic acids in the patients with MM showed strong correlation between each other, independent on the level of their activity, interactions differed individually. DNA-protein interactions were mostly expressed between intensities of DNA/RNA triad peaks and non-descriptive proteins, that were in agreement between BCC and SCC, but not in MM. Protein-protein interactions were similar among the patients, generally indicating the grade of activity in cells in tissues.

Paper Details

Date Published: 17 February 2011
PDF: 5 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78830T (17 February 2011); doi: 10.1117/12.874692
Show Author Affiliations
Natalja Skrebova Eikje, MC Professional OU (Estonia)


Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong; Justus F. R. Ilgner; Bodo E. Knudsen; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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