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Proceedings Paper

Assessment of basic instrumental performance of time-domain optical brain imagers
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Paper Abstract

To facilitate the design and optimization of instruments for time-domain optical brain imaging within the European project "nEUROPt", the performance of various instruments is assessed and compared. This type of instruments relies on picosecond lasers with high repetition rates, fast detectors and time-correlated single photon counting. The first step of the assessment included a number of basic tests that are related to parameters of the source, to the differential nonlinearity of the timing electronics and to the temporal instrument response function (IRF). An additional test has been devised to measure the responsivity of the detection system, i.e. the overall efficiency to collect and detect light emerging from tissue. Dedicated solid slab phantoms have been developed and quantitatively spectrally characterized to provide sources of known radiance with nearly Lambertian angular characteristics. The wavelength-dependent transmittance factor of these phantoms was of the order of 1020/(W s m2sr). Measurements of the responsivity of the detection systems of three time-domain optical brain imagers tested yielded similar values of the order of 0.1 mm2sr.

Paper Details

Date Published: 17 February 2011
PDF: 8 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 789602 (17 February 2011); doi: 10.1117/12.874654
Show Author Affiliations
Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
Antonio Pifferi, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie, CNR (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Dieter Richard Taubert, Physikalisch-Technische Bundesanstalt (Germany)
Mikhail Mazurenka, Physikalisch-Technische Bundesanstalt (Germany)
Oliver Steinkellner, Physikalisch-Technische Bundesanstalt (Germany)
Alexander Jelzow, Physikalisch-Technische Bundesanstalt (Germany)
Andrea Farina, Politecnico di Milano (Italy)
Ilaria Bargigia, Politecnico di Milano (Italy)
Davide Contini, Politecnico di Milano (Italy)
Matteo Caffini, Politecnico di Milano (Italy)
Lucia Zucchelli, Politecnico di Milano (Italy)
Lorenzo Spinelli, Istituto di Fotonica e Nanotecnologie, CNR (Italy)
Piotr Sawosz, Institute of Biocybernetics and Biomedical Engineering (Poland)
Adam Liebert, Institute of Biocybernetics and Biomedical Engineering (Poland)
Rainer Macdonald, Physikalisch-Technische Bundesanstalt (Germany)
Rinaldo Cubeddu, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie, CNR (Italy)


Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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