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Proceedings Paper

Multi-site and multi-depth in vivo cancer localization enhancement after autofluorescence removal
Author(s): Anne-Sophie Montcuquet; Lionel Hervé; Fabrice Navarro; Jean-Marc Dinten; Jérôme I. Mars
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Paper Abstract

Fluorescence imaging in diffusive media locates tumors tagged by injected fluorescent markers in NIR wave-lengths. For deep embedded markers, natural autofluorescence of tissues comes to be a limiting factor to tumor detection and accurate FDOT reconstructions. A spectroscopic approach coupled with Non-negative Matrix Factorization source separation method is explored to discriminate fluorescence sources according to their fluorescence spectra and remove unwanted autofluorescence. We successfully removed autofluorescence from acquisitions on living mice with a single subcutaneous tumor or two capillary tubes inserted at different depths.

Paper Details

Date Published: 17 February 2011
PDF: 10 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962S (17 February 2011); doi: 10.1117/12.874594
Show Author Affiliations
Anne-Sophie Montcuquet, CEA, LETI, MINATEC (France)
GIPSA-Lab., DIS (France)
Lionel Hervé, CEA, LETI, MINATEC (France)
Fabrice Navarro, CEA, LETI, MINATEC (France)
Jean-Marc Dinten, CEA, LETI, MINATEC (France)
Jérôme I. Mars, GIPSA-Lab., DIS (France)


Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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