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Proceedings Paper

Integrated lab-on-a-chip: a combined sample preparation and PCR system as an ultrafast analytical tool for pathogen detection
Author(s): Holger Becker; Nadine Hlawatsch; Richard Klemm; Claudia Gärtner
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Paper Abstract

Lab-on-a-chip systems are seen as a very promising approach for a decentralized continuous pathogen monitoring technology. In this paper, we present the development of a fully integrated device for the multiplexed nucleic-acid based identification of pathogens. Due to the complexity of such a fully integrated device, in a first development step, functional modules for the various process steps like lysis, DNA extraction and purification, continuous-flow PCR and detection have been developed and evaluated, allowing a functional verification prior to integration. All the modules as well as the final integrated device have been manufactured using scaleable industrial manufacturing methods, namely injection molding in order to facilitate commercialization.

Paper Details

Date Published: 11 February 2011
PDF: 5 pages
Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 792903 (11 February 2011); doi: 10.1117/12.874551
Show Author Affiliations
Holger Becker, microfluidic ChipShop GmbH (Germany)
Nadine Hlawatsch, microfluidic ChipShop GmbH (Germany)
Richard Klemm, microfluidic ChipShop GmbH (Germany)
Claudia Gärtner, microfluidic ChipShop GmbH (Germany)

Published in SPIE Proceedings Vol. 7929:
Microfluidics, BioMEMS, and Medical Microsystems IX
Holger Becker; Bonnie L. Gray, Editor(s)

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