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Proceedings Paper

Comparison of various methods to enhance laser photon density in soft tissue: tissue temperature, laser pulse modulation, glycerol, and their combination
Author(s): Changmin Yeo; Heesung Kang; Hunjeong Park; Byungjo Jung
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Paper Abstract

Recently, tissue optical clearing (TOC) has been considered as a useful tool in low level laser therapy due to the enhancement of photon density in deep tissue layer. In this study, glycerol injection, tissue temperature, laser pulse modulation, and their combination methods were investigated and compared by analyzing 2D and 3D laser beam profile. A thermal plate was built to control tissue temperature from 40°C through 10°C at 10°C decrement. A continuous laser of 660 nm was modulated at the frequencies of 1, 10, 25, and 50 Hz. 95% glycerol was injected into a region of interest of sample where laser is irradiated and its effect was analyzed after 5 min. Finally, their combination method was evaluated. Analysis was performed with the diffusion images acquired by CCD and the optical properties measured by double integrating sphere. Results demonstrated that average peak intensity of laser beam profile was 1) 1.57-fold higher at 10°C than 40°C, 2) 1.79-fold higher at 10 Hz than continuous wave, 3) 1.65-fold higher with 95% glycerol injection than no glycerol application, and 4) 2.52-fold higher at the combination method than independent methods. Average total intensity at FWHM was 1) 1.44-fold higher with tissue cooling, 2) 1.71-fold higher at 10 Hz, 3) 1.61-fold higher with glycerol injection, and 4) 2.19-fold higher with the combination method. In conclusion, this study implies that tissuecooling, pulse modulation, glycerol injection, and their combination method can effectively deliver laser photon in LLLT by enhancing the photon density in soft tissue.

Paper Details

Date Published: 17 February 2011
PDF: 10 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 788306 (17 February 2011); doi: 10.1117/12.874490
Show Author Affiliations
Changmin Yeo, Yonsei Univ. (Korea, Republic of)
Heesung Kang, Yonsei Univ. (Korea, Republic of)
Hunjeong Park, Yonsei Univ. (Korea, Republic of)
Byungjo Jung, Yonsei Univ. (Korea, Republic of)


Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory M.D.; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg M.D.; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong M.D.; Justus F. R. Ilgner M.D.; Bodo E. Knudsen M.D.; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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