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Proceedings Paper

3D tomographic breast imaging in-vivo using a handheld optical imager
Author(s): Sarah J. Erickson; Sergio Martinez; Jean Gonzalez; Manuela Roman; Annie Nunez; Anuradha Godavarty
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Paper Abstract

Hand-held optical imagers are currently developed toward clinical imaging of breast tissue. However, the hand-held optical devices developed to are not able to coregister the image to the tissue geometry for 3D tomography. We have developed a hand-held optical imager which has demonstrated automated coregistered imaging and 3D tomography in phantoms, and validated coregistered imaging in normal human subjects. Herein, automated coregistered imaging is performed in a normal human subject with a 0.45 cm3 spherical target filled with 1 μM indocyanine green (fluorescent contrast agent) placed superficially underneath the flap of the breast tissue. The coregistered image data is used in an approximate extended Kalman filter (AEKF) based reconstruction algorithm to recover the 3D location of the target within the breast tissue geometry. The results demonstrate the feasibility of performing 3D tomographic imaging and recovering a fluorescent target in breast tissue of a human subject for the first time using a hand-held based optical imager. The significance of this work is toward clinical imaging of breast tissue for cancer diagnostics and therapy monitoring.

Paper Details

Date Published: 17 February 2011
PDF: 8 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962H (17 February 2011); doi: 10.1117/12.874347
Show Author Affiliations
Sarah J. Erickson, Florida International Univ. (United States)
Sergio Martinez, Florida International Univ. (United States)
Jean Gonzalez, Florida International Univ. (United States)
Manuela Roman, Florida International Univ. (United States)
Annie Nunez, Florida International Univ. (United States)
Anuradha Godavarty, Florida International Univ. (United States)


Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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