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Proceedings Paper

Reduction of noise floor for molecular, fluorescence-enhanced optical imaging
Author(s): Banghe Zhu; John C. Rasmussen; Yujie Lu; Eva M. Sevick-Muraca
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Paper Abstract

Near infrared fluorescence (NIRF) optical imaging has been successfully demonstrated to offer a high specificity and sensitivity in detecting various diseases. However, the measurement sensitivity of NIRF optical imaging system is limited by strong backscattered excitation light leakage. Herein, appropriate filter combination and collimation optics was adapted to the NIRF optical imager. The sensitivity of near-infrared fluorescence imaging instrumentation can be dramatically improved upon using the appropriate filter combination and collimation optics. This validation and qualification approach to reduce the noise floor and improve sensitivity is presented a standardized metric for all fluorescence based imaging systems proposed.

Paper Details

Date Published: 22 February 2011
PDF: 7 pages
Proc. SPIE 7891, Design and Quality for Biomedical Technologies IV, 789104 (22 February 2011); doi: 10.1117/12.874331
Show Author Affiliations
Banghe Zhu, The Univ. of Texas Health Science Ctr. at Houston (United States)
John C. Rasmussen, The Univ. of Texas Health Science Ctr. at Houston (United States)
Yujie Lu, The Univ. of Texas Health Science Ctr. at Houston (United States)
Eva M. Sevick-Muraca, The Univ. of Texas Health Science Ctr. at Houston (United States)


Published in SPIE Proceedings Vol. 7891:
Design and Quality for Biomedical Technologies IV
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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