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Proceedings Paper

Molecular mechanism of PDT-induced apoptotic cells stimulation NO production in macrophages
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Paper Abstract

It is well known that apoptotic cells (AC) participate in immune response. The immune response induced by AC, either immunostimulatory or immunosuppressive, have been extensively studied. However, the molecular mechanisms of the immunostimulatory effects induced by PDT-treated AC remain unclear. Nitric oxide (NO) is an important signal transduction molecule and has been implicated in a variety of functions. It has also been found to play an important role not only as a cytotoxic effector but an immune regulatory mediator. In this study, we demonstrate that the PDT-induced apoptotic tumor cells stimulate the production of NO in macrophages by up-regulating expression of inducible nitric oxide synthase (iNOS). In addition, we show that AC, through toll-like receptors (TLRs), can activate myeloid differentiation factor-88 (MyD88), indicating that AC serves as an intercellular signal to induce iNOS expression in immune cells after PDT treatment. This study provided more details for understanding the molecular mechanism of the immune response induced by PDT-treated AC.

Paper Details

Date Published: 10 February 2011
PDF: 10 pages
Proc. SPIE 7900, Biophotonics and Immune Responses VI, 790008 (10 February 2011); doi: 10.1117/12.874324
Show Author Affiliations
Sheng Song, South China Normal Univ. (China)
Fei-fan Zhou, South China Normal Univ. (China)
Si-hua Yang, South China Normal Univ. (China)
Wei R. Chen, South China Normal Univ. (China)
Univ. of Central Oklahoma (United States)


Published in SPIE Proceedings Vol. 7900:
Biophotonics and Immune Responses VI
Wei R. Chen, Editor(s)

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