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Proceedings Paper

The high-quality spectral fingerprint of glucose captured by Raman spectroscopy in non-invasive glucose measurement
Author(s): Jeankun Oh; Seongmoon Cho; Hyunho Oh; Yunhee Ku; BongChu Shim; Moosub Kim; Yongju Yang; Dami Kim; Hyejin Eum; David R. Miller
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Paper Abstract

Optical spectroscopy has the inherent advantage of directly measuring glucose levels by means of the unique nature of a spectral fingerprint for the target analyte, glucose, which is determined in the form of a calibration spectrum (a product of multivariate analysis method). The literature is replete with claims of successful in-vivo glucose measurements in terms of Clark error grid analysis. However, all of them fail to demonstrate an in vivo glucose-specific calibration spectrum. In this study we use Raman spectroscopy to capture a high quality spectral fingerprint of the glucose molecule noninvasively and demonstrate calculated correlation coefficients between a pure glucose spectrum and calibration spectra at over 0.8.

Paper Details

Date Published: 10 February 2011
PDF: 8 pages
Proc. SPIE 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 79060G (10 February 2011); doi: 10.1117/12.874314
Show Author Affiliations
Jeankun Oh, LG Electronics Inc. (Korea, Republic of)
Seongmoon Cho, LG Electronics Inc. (Korea, Republic of)
Hyunho Oh, LG Electronics Inc. (Korea, Republic of)
Yunhee Ku, LG Electronics Inc. (Korea, Republic of)
BongChu Shim, LG Electronics Inc. (Korea, Republic of)
Moosub Kim, LG Electronics Inc. (Korea, Republic of)
Yongju Yang, LG Electronics Inc. (Korea, Republic of)
Dami Kim, LG Electronics Inc. (Korea, Republic of)
Hyejin Eum, LG Electronics Inc. (Korea, Republic of)
David R. Miller, LG Electronics Inc. (Korea, Republic of)


Published in SPIE Proceedings Vol. 7906:
Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III
Gerard L. Coté; Robert J. Nordstrom, Editor(s)

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