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Proceedings Paper

Assessment of bone healing on tibial fractures treated with wire osteosynthesis associated or not with infrared laser light and biphasic ceramic bone graft (HATCP) and guided bone regeneration (GBR): Raman spectroscopy study
Author(s): Fabíola Bastos de Carvalho; Gilberth Tadeu S. Aciole; Jouber Mateus S. Aciole; Landulfo Silveira Jr.; Jean Nunes dos Santos; Antônio L. Barbosa Pinheiro
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Paper Abstract

The aim of this study was to evaluate, through Raman spectroscopy, the repair of complete tibial fracture in rabbits fixed with wire osteosynthesis - WO, treated or not with infrared laser light (λ 780nm, 50mW, CW) associated or not to the use of HATCP and GBR. Surgical fractures were created under general anesthesia (Ketamine 0.4ml/Kg IP and Xilazine 0.2ml/Kg IP), on the tibia of 15 rabbits that were divided into 5 groups and maintained on individual cages, at day/night cycle, fed with solid laboratory pelted diet and had water ad libidum. On groups II, III, IV and V the fracture was fixed with WO. Animals of groups III and V were grafted with hydroxyapatite + GBR technique. Animals of groups IV and V were irradiated at every other day during two weeks (16J/cm2, 4 x 4J/cm2). Observation time was that of 30 days. After animal death the specimens were kept in liquid nitrogen for further analysis by Raman spectroscopy. Raman spectroscopy showed significant differences between groups (p<0.001). It is concluded that IR laser light was able to accelerate fracture healing and the association with HATCP and GBR resulted on increased deposition of calcium hydroxyapatite.

Paper Details

Date Published: 17 February 2011
PDF: 6 pages
Proc. SPIE 7887, Mechanisms for Low-Light Therapy VI, 78870T (17 February 2011); doi: 10.1117/12.874288
Show Author Affiliations
Fabíola Bastos de Carvalho, Federal Univ. of Bahia (Brazil)
Gilberth Tadeu S. Aciole, Federal Univ. of Bahia (Brazil)
Jouber Mateus S. Aciole, Federal Univ. of Bahia (Brazil)
Landulfo Silveira Jr., Camilo Castelo Branco Univ. (Brazil)
Jean Nunes dos Santos, Federal Univ. of Bahia (Brazil)
Antônio L. Barbosa Pinheiro, Federal Univ. of Bahia (Brazil)
Camilo Castelo Branco Univ. (Brazil)
National Institute of Optics and Photonics (Brazil)

Published in SPIE Proceedings Vol. 7887:
Mechanisms for Low-Light Therapy VI
Michael R. Hamblin; Ronald W. Waynant; Juanita Anders, Editor(s)

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