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Proceedings Paper

Time-domain fluorescence diffuse optical tomography for living animals by total-light algorithm
Author(s): Goro Nishimura; Kamlesh Awasthi; Kitsakorn Locharoenrat; Shinpei Okawa; Yukio Yamada
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Paper Abstract

We are reporting the first trial image reconstruction of a implanted fluorescent target into a live rat abdomen. We use a simplified algorithm for fluorescence diffuse optical tomography (FDOT), so-called the Total-light algorithm to obtain the absorption image of the target from the measured mean-transit time (MTT). We reconstructed two absorption images with and without a fluorescence target. It is difficult to identify something in the absorption images. However, the difference image between the two images highlights the target. This suggests that our algorithm is robust to the artifacts in the images in the real situation of in vivo measurements.

Paper Details

Date Published: 17 February 2011
PDF: 7 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962Q (17 February 2011); doi: 10.1117/12.874275
Show Author Affiliations
Goro Nishimura, Hokkaido Univ. (Japan)
Kamlesh Awasthi, Hokkaido Univ. (Japan)
Kitsakorn Locharoenrat, Hokkaido Univ. (Japan)
Shinpei Okawa, The Univ. of Electro-Communications (Japan)
Yukio Yamada, The Univ. of Electro-Communications (Japan)

Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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