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Proceedings Paper

Dual-modality in vivo imaging for MRI detection of tumors and NIRF-guided surgery using multi-component nanoparticles
Author(s): Jaehong Key; Kwangmeyung Kim; Deepika Dhawan; Deborah W. Knapp; Ick Chan Kwon; Kuiwon Choi; James F. Leary
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Paper Abstract

Magnetic resonance imaging (MRI) is one of the best imaging modalities for noninvasive cancer detection but MRI does not have enough sensitivity to delineate tumor margins during surgery. Moreover, since most surgical tools contain metal substances, image-guided surgery is hard to perform with a MR machine using magnets. Also, MR imaging is too slow for real-time guided-surgery. On the other hand, near infrared fluorescence (NIRF) imaging has recently received great interest for in vivo imaging due to its high signal-to-noise ratios and short image-acquisition times. NIRF imaging can be used to delineate tumor margins during surgery, but current NIRF imaging cannot provide the penetration depth to detect early-stage cancer inside body. Thus, we have developed dual-modality in vivo imaging for MRI detection of tumors and NIRF-guided surgery using multi-component nanoparticles. NIRF dye (cyanine 5.5, Cy5.5), conjugated glycol chitosan nanoparticles (HGC) exhibited excellent tumor targeting ability with NIRF imaging. Superparamagnetic iron oxide (SPIO) nanoparticles as a MR contrast agent were loaded into the nanoparticles, resulting in SPIO-HGC-Cy5.5 nanoparticles. SPIO-HGC-Cy5.5 nanoparticles were characterized and evaluated in mice by both NIRF and MR imaging. Our results indicate SPIO-HGC-Cy5.5 nanoparticles have the potential for dual-modality in vivo imaging with MRI detection of tumors and NIRF-guided surgery.

Paper Details

Date Published: 11 February 2011
PDF: 8 pages
Proc. SPIE 7908, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VIII, 790805 (11 February 2011); doi: 10.1117/12.874241
Show Author Affiliations
Jaehong Key, Purdue Univ. (United States)
Kwangmeyung Kim, Korea Institute of Science and Technology (Korea, Republic of)
Deepika Dhawan, Purdue Univ. (United States)
Deborah W. Knapp, Purdue Univ. (United States)
Ick Chan Kwon, Korea Institute of Science and Technology (Korea, Republic of)
Kuiwon Choi, Korea Institute of Science and Technology (Korea, Republic of)
James F. Leary, Purdue Univ. (United States)


Published in SPIE Proceedings Vol. 7908:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VIII
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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