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Proceedings Paper

Detecting lower extremity vascular dynamics in patients with peripheral artery disease using diffuse optical tomography
Author(s): Michael A. Khalil; Hyun-Keol K. Kim; In-Kyong Kim; Rajeev Dayal; Andreas H. Hielscher
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Paper Abstract

Peripheral Artery Disease (PAD) affects over 10 million Americans and is associated with significant morbidity and mortality. While in many cases the ankle-brachial index (ABI) can be used for diagnosing the disease, this parameter is not dependable in the diabetic and elderly population. These populations tend to have calcified arteries, which leads to elevated ABI values. Dynamic optical tomography (DDOT) promises to overcome the limitations of the current diagnostic techniques and has the potential to initiate a paradigm shift in the diagnosis of vascular disease. We have performed initial pilot studies involving 5 PAD patients and 3 healthy volunteers. The time traces and tomographic reconstruction obtained from measurements on the feet show significant differences between healthy and affected vasculatures. In addition, we found that DOT is capable of identifying PAD in diabetic patients, who are misdiagnosed by the traditional ABI screening.

Paper Details

Date Published: 17 February 2011
PDF: 6 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962Z (17 February 2011); doi: 10.1117/12.874236
Show Author Affiliations
Michael A. Khalil, Columbia Univ. (United States)
Hyun-Keol K. Kim, Columbia Univ. (United States)
In-Kyong Kim, New York Presbyterian Hospital (United States)
Rajeev Dayal, New York Presbyterian Hospital (United States)
Andreas H. Hielscher, Columbia Univ. (United States)


Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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