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Proceedings Paper

Optical control of urinary bladder contraction using femtosecond-pulsed laser
Author(s): Jonghee Yoon; Myunghwan Choi; Chulhee Choi
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Paper Abstract

Even though catheterization or electric stimulation are used for treatment of neurogenic bladder, invasiveness and inconvenience of these approaches prompt us to develop a new possible therapeutic method to control urination by using optical stimulation. The optical method using femtosecond pulsed laser (FSPL) has advantages of focused and subsurface stimulation. Irradiation of FSPL induced a rapid increase of intracellular calcium level followed by contraction of primary cultured human bladder smooth muscle cells. Short exposure of bladder detrusor ex-vivo to FSPL also induced a controlled contraction of detrusor. Collectively, we propose that FSPL can be considered as a potential therapeutic approach for intractable neurogenic bladder.

Paper Details

Date Published: 18 February 2011
PDF: 4 pages
Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 789714 (18 February 2011); doi: 10.1117/12.874022
Show Author Affiliations
Jonghee Yoon, KAIST (Korea, Republic of)
Myunghwan Choi, KAIST (Korea, Republic of)
Chulhee Choi, KAIST (Korea, Republic of)

Published in SPIE Proceedings Vol. 7897:
Optical Interactions with Tissue and Cells XXII
E. Duco Jansen; Robert J. Thomas, Editor(s)

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