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Proceedings Paper

Integrated scanning laser ophthalmoscopy and optical coherence tomography for quantitative multimodal imaging of retinal degeneration and autofluorescence
Author(s): Ali Issaei; Lukasz Szczygiel; Nima Hossein-Javaheri; Mei Young; L. L. Molday; R. S. Molday; M. V. Sarunic
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Paper Abstract

Scanning Laser Ophthalmoscopy (SLO) and Coherence Tomography (OCT) are complimentary retinal imaging modalities. Integration of SLO and OCT allows for both fluorescent detection and depth- resolved structural imaging of the retinal cell layers to be performed in-vivo. System customization is required to image rodents used in medical research by vision scientists. We are investigating multimodal SLO/OCT imaging of a rodent model of Stargardt's Macular Dystrophy which is characterized by retinal degeneration and accumulation of toxic autofluorescent lipofuscin deposits. Our new findings demonstrate the ability to track fundus autofluorescence and retinal degeneration concurrently.

Paper Details

Date Published: 10 February 2011
PDF: 8 pages
Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 789209 (10 February 2011); doi: 10.1117/12.873982
Show Author Affiliations
Ali Issaei, Simon Fraser Univ. (Canada)
Lukasz Szczygiel, Simon Fraser Univ. (Canada)
Nima Hossein-Javaheri, Simon Fraser Univ. (Canada)
Mei Young, Simon Fraser Univ. (Canada)
L. L. Molday, Univ. of British Columbia (Canada)
R. S. Molday, Univ. of British Columbia (Canada)
M. V. Sarunic, Simon Fraser Univ. (Canada)

Published in SPIE Proceedings Vol. 7892:
Multimodal Biomedical Imaging VI
Fred S. Azar; Xavier Intes, Editor(s)

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