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Proceedings Paper

Steroid-induced osteoporosis monitored by Raman spectroscopy
Author(s): Jason R. Maher; Masahiko Takahata; Hani A. Awad; Andrew J. Berger
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Paper Abstract

Glucocorticoids are frequently used to treat inflammatory disorders such as rheumatoid arthritis. Unfortunately, extended exposure to this steroid is the leading cause of physician-induced osteoporosis, leaving patients susceptible to fractures at rates of 30-50%. In this presentation, we report correlations between Raman spectra and biomechanical strength tests on bones of glucocorticoid- and placebo- treated mice. Both wild-type mice and a transgenic model of rheumatoid arthritis have been studied. A two-way ANOVA model reveals statistically significant spectral differences as influenced by glucocorticoid treatment and mouse type.

Paper Details

Date Published: 18 February 2011
PDF: 7 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78834H (18 February 2011); doi: 10.1117/12.873953
Show Author Affiliations
Jason R. Maher, Univ. of Rochester (United States)
Masahiko Takahata, Univ. of Rochester (United States)
Hani A. Awad, Univ. of Rochester (United States)
Andrew J. Berger, Univ. of Rochester (United States)


Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Andreas Mandelis; Henry Hirschberg; Steen J. Madsen; Hyun Wook Kang; Bodo E. Knudsen; Anita Mahadevan-Jansen; E. Duco Jansen; Brian Jet-Fei Wong; Justus F. R. Ilgner, Editor(s)

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