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Proceedings Paper

Near-infrared optical mammography with broadband spectral imaging for spatially resolved oximetry
Author(s): Yang Yu; Angelo Sassaroli; Marc J. Homer; Roger A. Graham; Sergio Fantini
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Paper Abstract

We report the development of an instrument for diffuse spectral imaging of the human breast operating over the wavelength range 650-900 nm. This instrument images the slightly compressed human breast in a planar geometry by performing a tandem scan, over the x-y plane, of a 3 mm illumination optical fiber and a 5 mm collection optical fiber that are collinear and located on opposite sides of the breast. An edge-correction algorithm accounts for breast thickness variability over the x-y plane, a second-derivative imaging algorithm enhances the display of optical inhomogeneities, and a paired-wavelength spectral method yields oxygenation maps. We report our results of oxygenation mapping in eighteen human subjects, two of which are breast cancer patients, one with a ductal carcinoma in situ, the other with an invasive ductal carcinoma.

Paper Details

Date Published: 17 February 2011
PDF: 9 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962G (17 February 2011); doi: 10.1117/12.873945
Show Author Affiliations
Yang Yu, Tufts Univ. (United States)
Angelo Sassaroli, Tufts Univ. (United States)
Marc J. Homer, Tufts Medical Ctr. (United States)
Roger A. Graham, Tufts Medical Ctr. (United States)
Sergio Fantini, Tufts Univ. (United States)

Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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