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Proceedings Paper

Visualization of human retinal micro-capillaries with phase contrast high-speed optical coherence tomography
Author(s): Dae Yu Kim; Jeff Fingler; John S. Werner; Daniel M. Schwartz; Scott E. Fraser; Robert J. Zawadzki
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Paper Abstract

We present high-speed Fourier-domain optical coherence tomography (Fd-OCT) with the phase variance based motion contrast method for visualizing retinal micro-circulation in vivo. This technique allows non-invasive visualization of a two-dimensional retinal perfusion map and concurrent volumetric morphology of retinal microvasculature with high sensitivity. The high-speed acquisition rate at 125kHz A-scans enables reduction of motion artifacts with increased scanning area if compared to previously reported results. Several scanning schemes with different sampling densities and scanning areas are evaluated to find optimal parameters for in vivo imaging. In order to evaluate this technique, we compare OCT micro-capillary imaging using the phase variance technique with fundus fluorescein angiography (FA). Additionally, volumetric visualization of blood flow for a normal subject is presented.

Paper Details

Date Published: 16 February 2011
PDF: 6 pages
Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 78890H (16 February 2011); doi: 10.1117/12.873896
Show Author Affiliations
Dae Yu Kim, Univ. of California, Davis (United States)
Jeff Fingler, California Institute of Technology (United States)
John S. Werner, Univ. of California Davis (United States)
Daniel M. Schwartz, Univ. of California, San Francisco (United States)
Scott E. Fraser, California Institute of Technology (United States)
Robert J. Zawadzki, Univ. of California, Davis (United States)


Published in SPIE Proceedings Vol. 7889:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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