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Proceedings Paper

Compact and highly stable quantum dots through optimized aqueous phase transfer
Author(s): Sudarsan Tamang; Grégory Beaune; Cathy Poillot; Michel De Waard; Isabelle Texier-Nogues; Peter Reiss
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Paper Abstract

A large number of different approaches for the aqueous phase transfer of quantum dots have been proposed. Surface ligand exchange with small hydrophilic thiols, such as L-cysteine, yields the lowest particle hydrodynamic diameter. However, cysteine is prone to dimer formation, which limits colloidal stability. We demonstrate that precise pH control during aqueous phase transfer dramatically increases the colloidal stability of InP/ZnS quantum dots. Various bifunctional thiols have been applied. The formation of disulfides, strongly diminishing the fluorescence QY has been prevented through addition of appropriate reducing agents. Bright InP/ZnS quantum dots with a hydrodynamic diameter <10 nm and long-term stability have been obtained. Finally we present in vitro studies of the quantum dots functionalized with the cell-penetrating peptide maurocalcine.

Paper Details

Date Published: 11 February 2011
PDF: 6 pages
Proc. SPIE 7909, Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI, 79091B (11 February 2011); doi: 10.1117/12.873805
Show Author Affiliations
Sudarsan Tamang, CEA-CNRS, Univ. Joseph Fourier (France)
Grégory Beaune, CEA-CNRS, Univ. Joseph Fourier (France)
CEA-Grenoble, LETI-DTBS (France)
Cathy Poillot, INSERM, Univ. Joseph Fourier (France)
Michel De Waard, INSERM, Univ. Joseph Fourier (France)
Isabelle Texier-Nogues, CEA-Grenoble, LETI-DTBS (France)
Peter Reiss, CEA-CNRS, Univ. Joseph Fourier (France)

Published in SPIE Proceedings Vol. 7909:
Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI
Wolfgang J. Parak; Kenji Yamamoto M.D.; Marek Osinski, Editor(s)

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