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Proceedings Paper

Quantitative evaluation of systematic imaging error due to uncertainty in tissue optical properties in high-density diffuse optical tomography
Author(s): Yuxuan Zhan; Adam Eggebrecht; Hamid Dehghani; Joseph Culver
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Paper Abstract

In MRI-guided diffuse optical tomography of the human brain function, three-dimensional anatomical head model consisting of up to five segmented tissue types can be specified. With disregard to misclassification between different tissues, uncertainty in the optical properties of each tissue type becomes the dominant cause of systematic error in image reconstruction. In this study we present a quantitative evaluation of image resolution dependence due to such uncertainty. Our results show that given a head model which provides a realistic description of its tissue optical property distribution, high-density diffuse optical tomography with cortically constrained image reconstruction are capable of detecting focal activation up to 21.81 mm below the human scalp at an imaging quality better than or equal to 1.0 cm in localization error and 1.0 cm3 in FVHM with a tolerance of uncertainty in tissue optical properties between +15% and -20%.

Paper Details

Date Published: 1 March 2011
PDF: 8 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78960O (1 March 2011); doi: 10.1117/12.873746
Show Author Affiliations
Yuxuan Zhan, The Univ. of Birmingham (United Kingdom)
Adam Eggebrecht, Washington Univ. in St. Louis (United States)
Hamid Dehghani, The Univ. of Birmingham (United Kingdom)
Joseph Culver, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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