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Proceedings Paper

Biophotonics and laser-optical technologies for controlling gas-exchange processes in biological tissue
Author(s): M. M. Asimov; R. Asimov; A. N. Rubinov
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Paper Abstract

Laser-tissue interaction at low energy (cold) laser radiation and especially the light impact on gas exchange in biological tissue is a one of interesting aspects of modern photomedicine and photobiology. The results of in vivo investigations of laser-induced photodissosiation of oxyhemoglobin in cutaneous blood vessels and its role in tissue oxygenation are presented. Laser-induced photodissosiation of oxyhemoglobin in vivo experimentally investigated by two independent methods: pules oximetry and polarographic transcutaneous oxygen monitoring. Unique possibility of enhancing cell metabolism due to the local increase of the molecular oxygen concentration in tissue is demonstrated. New method of dosimetry in phototherapy as well as laser therapy based on local tissue oxygenation and stimulation of aerobic cell metabolism is developed. Novel optical method of photodecomposition of blood carboxyhemoglobin and elimination of poisoning effect of carbon monoxide is developed. It is experimentally shown that light induced photodissosiation of carboxyhemoglobin decreases the time of restoring the normal function of hemoglobin to carry of oxygen approximately by order of magnitude. Laser-optical method of local tissue oxygenation based on laser-induced in vivo photodissociation of oxyhemoglobin in cutaneous blood vessels is proposed. The results of experimental study and computer modeling the kinetics of tissue oxygen distribution from blood plasma are presented. Different biomedical applications the effect of light and cold laser radiation on controlling gas exchange in biological tissue are discussed.

Paper Details

Date Published:
PDF: 8 pages
Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 78971O; doi: 10.1117/12.873732
Show Author Affiliations
M. M. Asimov, B.I. Stepanov Institute of Physics (Belarus)
R. Asimov, Sensotronica Ltd. (Belarus)
A. N. Rubinov, B.I. Stepanov Institute of Physics (Belarus)

Published in SPIE Proceedings Vol. 7897:
Optical Interactions with Tissue and Cells XXII
E. Duco Jansen; Robert J. Thomas, Editor(s)

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