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Proceedings Paper

Near-infrared dipyrrin-based fluorogenic chelators for metal ions
Author(s): Sujatha Thyagarajan; Brahma Ghosh; Mikhail A. Filatov; Anna V. Moore; Andrei V. Cheprakov; Sergei A. Vinogradov
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Paper Abstract

We present a new family of dipyrrins, whose spectral properties are tunable over the visible/near infrared range by way of annealing the pyrrolic residues with external aromatic fragments. Complexes of the π-extended with many metal ions were found to be highly fluorescent, and their fluorescence is modulated depending on the mode of the metal coordination. Structural and spectroscopic data were consolidated on the basis of the Kasha's exciton coupling theory, suggesting rational pathways to practically useful fluorogenic dipyrrin-based ligands. Water-soluble dendritic π- extended dipyrrin BDP-1 was prepared and evaluated as a fluorescent sensor for Zn2+. BDP-1 shows micromolar binding affinity for Zn2+ and high selectivity compared to Ca2+, Mg2+ and many other metal ions.

Paper Details

Date Published: 11 February 2011
PDF: 9 pages
Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79100Z (11 February 2011); doi: 10.1117/12.873654
Show Author Affiliations
Sujatha Thyagarajan, Univ. of Pennsylvania (United States)
Brahma Ghosh, Massachusetts General Hospital (United States)
Mikhail A. Filatov, Lomonosov Moscow State Univ. (Russian Federation)
Anna V. Moore, Massachusetts General Hospital (United States)
Andrei V. Cheprakov, Lomonosov Moscow State Univ. (Russian Federation)
Sergei A. Vinogradov, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 7910:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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