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Proceedings Paper

Fluorescence-enhanced optical tomography using phase information
Author(s): Yujie Lu; Eva M. Sevick-Muraca
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Paper Abstract

Fluorescence-enhanced optical imaging/tomography (FEOI/FEOT) could play an important role in drug discovery and clinical diagnostics. In recent years, improvement in spatial resolution and quantitative biological information has been increasingly promised. Time- and frequency-resolved FEOT has great potential to obtain improved reconstruction information compared with continuous wave (CW) mode due to the acquisition of more measurement information. In this paper, a phase-only FEOT(PO-FEOT) is proposed and evaluated. In PO-FEOT, a finite element-based linear relationship between the unknown fluorophore variables and phase information obtained from time- and frequency-domain boundary measurements is used in FEOT reconstruction. Synthetic data shows that, compared to the amplitude and phase-based reconstruction, the reconstruction time cost is remarkably reduced when phase is used alone. The reconstructed results show that PO-FEOT with high frequency information can acquire preferable reconstruction quality.

Paper Details

Date Published: 17 February 2011
PDF: 8 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78960K (17 February 2011); doi: 10.1117/12.873589
Show Author Affiliations
Yujie Lu, The Univ. of Texas Health Science Ctr. at Houston (United States)
Eva M. Sevick-Muraca, The Univ. of Texas Health Science Ctr. at Houston (United States)

Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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