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Proceedings Paper

Evaluation of the accuracy of brain optical properties estimation at different ages using the frequency-domain multi-distance method
Author(s): Mathieu Dehaes; P. Ellen Grant; Danielle D. Sliva; Nadège Roche-Labarbe; Rudolph Pienaar; David A. Boas; Maria Angela Franceschini; Juliette Selb
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Paper Abstract

NIRS is safe, non-invasive and offers the possibility to record local hemodynamic parameters at the bedside, avoiding the transportation of neonates and critically ill patients. In this work, we evaluate the accuracy of the frequency-domain multi-distance (FD-MD) method to retrieve brain optical properties from neonate to adult. Realistic measurements are simulated using a 3D Monte Carlo modeling of light propagation. Height different ages were investigated: a term newborn of 38 weeks gestational age, two infants of 6 and 12 months of age, a toddler of 2 year (yr.) old, two children of 5 and 10 years of age, a teenager of 14 yr. old, and an adult. Measurements are generated at multiple distances on the right parietal area of head models and fitted to a homogeneous FD-MD model to estimate the brain optical properties. In the newborn, infants, toddler and 5 yr. old child models, the error was dominated by the head curvature, while the superficial layer in the 10 yr. old child, teenager and adult heads. The influence of the CSF is also evaluated. In this case, absorption coefficients suffer from an additional error. In all cases, measurements at 5 mm provided worse estimation because of the diffusion approximation.

Paper Details

Date Published: 10 February 2011
PDF: 12 pages
Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 789203 (10 February 2011); doi: 10.1117/12.873562
Show Author Affiliations
Mathieu Dehaes, Children's Hospital Boston (United States)
Harvard Medical School (United States)
P. Ellen Grant, Children's Hospital Boston (United States)
Harvard Medical School (United States)
Massachusetts General Hospital (United States)
Danielle D. Sliva, Children's Hospital Boston (United States)
Harvard Medical School (United States)
Nadège Roche-Labarbe, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Rudolph Pienaar, Children's Hospital Boston (United States)
Harvard Medical School (United States)
David A. Boas, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Maria Angela Franceschini, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Juliette Selb, Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 7892:
Multimodal Biomedical Imaging VI
Fred S. Azar; Xavier Intes, Editor(s)

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