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Proceedings Paper

Endoscopic detection of murine colonic dysplasia using a novel fluorescence-labeled peptide
Author(s): Sharon J. Miller; Bishnu P. Joshi; Adam Gaustad; Eric R. Fearon; Thomas D. Wang
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Paper Abstract

Current endoscopic screening does not detect all pre-malignant (dysplastic) colorectal mucosa, thus requiring the development of more sensitive, targeted techniques to improve detection. The presented work utilizes phage display to identify a novel peptide binder to colorectal dysplasia in a CPC;Apc mouse model. A wide-field, small animal endoscope capable of fluorescence excitation (450-475 nm) identified polyps via white light and also collected fluorescence images (510 nm barrier filter) of peptide binding. The peptide bound ~2-fold greater to the colonic adenomas when compared to the control peptide. We have imaged fluorescence-labeled peptide binding in vivo that is specific towards distal colonic adenomas.

Paper Details

Date Published: 22 February 2011
PDF: 8 pages
Proc. SPIE 7893, Endoscopic Microscopy VI, 789303 (22 February 2011); doi: 10.1117/12.873530
Show Author Affiliations
Sharon J. Miller, Univ. of Michigan (United States)
Bishnu P. Joshi, Univ. of Michigan (United States)
Adam Gaustad, Univ. of Michigan (United States)
Eric R. Fearon, Univ. of Michigan (United States)
Thomas D. Wang, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 7893:
Endoscopic Microscopy VI
Guillermo J. Tearney; Thomas D. Wang, Editor(s)

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