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Proceedings Paper

An investigation on fluorescent-optical dual-mode tomography using time-resolved data
Author(s): Limin Zhang; Wei Zhang; Feng Gao; Jiao Li; Huijuan Zhao
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Paper Abstract

We present a scheme for fluorescence guided diffusion optical tomography to reconstruct the fluorescence parameters (yield and lifetime) and optical parameters (absorption and reduced coefficients) based on time-resolved data. In this paper, the fluorescence parameters were reconstructed at first, then the fluorescence images were used to guide and constrain the diffusion optical tomography reconstruction, and the binary image segmentation strategy was applied to improve the image quality in DOT. To validate the proposed method, the numerical simulation was performed to demonstrate its computational efficacy. The results showed the feasibility of this method, and the spatial resolution, quantification and computational efficiency in DOT were enhanced evidently.

Paper Details

Date Published: 21 February 2011
PDF: 7 pages
Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920Q (21 February 2011); doi: 10.1117/12.873361
Show Author Affiliations
Limin Zhang, Tianjin Univ. (China)
Wei Zhang, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Jiao Li, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 7892:
Multimodal Biomedical Imaging VI
Fred S. Azar; Xavier Intes, Editor(s)

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