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Proceedings Paper

Different optical spectral characteristics in a necrotic transmissible venereal tumor and a cystic lesion in the same canine prostate observed by triple-band trans-rectal optical tomography under trans-rectal ultrasound guidance
Author(s): Zhen Jiang; G. Reed Holyoak; Jerry W. Ritchey; Kenneth E. Bartels; Kendra Rock; Charlotte L. Ownby; Gennady Slobodov; Charles F. Bunting; Daqing Piao
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Paper Abstract

Different optical spectral characteristics were observed in a necrotic transmissible venereal tumor (TVT) and a cystic lesion in the same canine prostate by triple-wavelength trans-rectal optical tomography under trans-rectal ultrasound (TRUS) guidance. The NIR imager acquiring at 705nm, 785nm and 808nm was used to quantify both the total hemoglobin concentration (HbT) and oxygen saturation (StO2) in the prostate. The TVT tumor in the canine prostate as a model of prostate cancer was induced in a 7-year old, 27 kg dog. A 2 mL suspension of 2.5x106 cells/mL of homogenized TVT cells recovered from an in vivo subcutaneously propagated TVT tumor in an NOD/SCID mouse were injected in the cranial aspect of the right lobe of the canine prostate. The left lobe of the prostate had a cystic lesion present before TVT inoculation. After the TVT homogenate injection, the prostate was monitored weekly over a 9-week period, using trans-rectal NIR and TRUS in grey-scale and Doppler. A TVT mass within the right lobe developed a necrotic center during the later stages of this study, as the mass presented with substantially increased [HbT] in the periphery, with an area of reduced StO2 less than the area of the mass itself shown on ultrasonography. Conversely, the cystic lesion presented with slightly increased [HbT] in the periphery of the lesion shown on ultrasound with oxygen-reduction inside and in the periphery of the lesion. There was no detectable change of blood flow on Doppler US in the periphery of the cystic lesion. The slightly increased [HbT] in the periphery of the cystic lesion was correlated with intra-lesional hemorrhage upon histopathologic examination.

Paper Details

Date Published: 10 February 2011
PDF: 10 pages
Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920P (10 February 2011); doi: 10.1117/12.873144
Show Author Affiliations
Zhen Jiang, Oklahoma State Univ. (United States)
G. Reed Holyoak, Oklahoma State Univ. (United States)
Jerry W. Ritchey, Oklahoma State Univ. (United States)
Kenneth E. Bartels, Oklahoma State Univ. (United States)
Kendra Rock, Oklahoma State Univ. (United States)
Charlotte L. Ownby, Oklahoma State Univ. (United States)
Gennady Slobodov, The Univ. of Oklahoma Health Sciences Ctr. (United States)
Charles F. Bunting, Oklahoma State Univ. (United States)
Daqing Piao, Oklahoma State Univ. (United States)


Published in SPIE Proceedings Vol. 7892:
Multimodal Biomedical Imaging VI
Fred S. Azar; Xavier Intes, Editor(s)

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