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Proceedings Paper

A patient-specific visualization tool for comprehensive analysis of coronary CTA and perfusion MRI data
Author(s): H. A. Kirisli; V. Gupta; S. Kirschbaum; L. Neefjes; R. J. van Geuns; N. Mollet; B. P. F. Lelieveldt; J. H. C. Reiber; T. van Walsum; W. J. Niessen
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Paper Abstract

Cardiac magnetic resonance perfusion imaging (CMR) and computed tomography angiography (CTA) are widely used to assess heart disease. CMR is used to measure the global and regional myocardial function and to evaluate the presence of ischemia; CTA is used for diagnosing coronary artery disease, such as coronary stenoses. Nowadays, the hemodynamic significance of coronary artery stenoses is determined subjectively by combining information on myocardial function with assumptions on coronary artery territories. As the anatomy of coronary arteries varies greatly between individuals, we developed a patient-specific tool for relating CTA and perfusion CMR data. The anatomical and functional information extracted from CTA and CMR data are combined into a single frame of reference. Our graphical user interface provides various options for visualization. In addition to the standard perfusion Bull's Eye Plot (BEP), it is possible to overlay a 2D projection of the coronary tree on the BEP, to add a 3D coronary tree model and to add a 3D heart model. The perfusion BEP, the 3D-models and the CTA data are also interactively linked. Using the CMR and CTA data of 14 patients, our tool directly established a spatial correspondence between diseased coronary artery segments and myocardial regions with abnormal perfusion. The location of coronary stenoses and perfusion abnormalities were visualized jointly in 3D, thereby facilitating the study of the relationship between the anatomic causes of a blocked artery and the physiological effects on the myocardial perfusion. This tool is expected to improve diagnosis and therapy planning of early-stage coronary artery disease.

Paper Details

Date Published: 1 March 2011
PDF: 9 pages
Proc. SPIE 7964, Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling, 796410 (1 March 2011); doi: 10.1117/12.873050
Show Author Affiliations
H. A. Kirisli, Erasmus MC (Netherlands)
Leiden Univ. Medisch Ctr. (Netherlands)
V. Gupta, Leiden Univ. Medisch Ctr. (Netherlands)
Delft Univ. of Technology (Netherlands)
S. Kirschbaum, Erasmus MC (Netherlands)
L. Neefjes, Erasmus MC (Netherlands)
R. J. van Geuns, Erasmus MC (Netherlands)
N. Mollet, Erasmus MC (Netherlands)
B. P. F. Lelieveldt, Leiden Univ. Medisch Ctr. (Netherlands)
Delft Univ. of Technology (Netherlands)
J. H. C. Reiber, Leiden Univ. Medisch Ctr. (Netherlands)
T. van Walsum, Erasmus MC (Netherlands)
W. J. Niessen, Erasmus MC (Netherlands)
Delft Univ. of Technology (Netherlands)

Published in SPIE Proceedings Vol. 7964:
Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling
Kenneth H. Wong; David R. Holmes III, Editor(s)

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