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Proceedings Paper

Fourier domain low coherence interferometry for detection of early colorectal cancer development in the AOM rat model
Author(s): Francisco E. Robles; Yizheng Zhu; Jin Lee; Sheela Sharma; Adam Wax
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Paper Abstract

We present Fourier domain low coherence interferometry (fLCI) applied to the detection of preneoplastic changes in the colon using the ex-vivo azoxymethane (AOM) rat carcinogenesis model. fLCI measures depth resolved spectral oscillations, also known as local oscillations, resulting from coherent fields induced by the scattering of cell nuclei. The depth resolution of fLCI permits nuclear morphology measurements within thick tissues, making the technique sensitive to the earliest stages of precancerous development. To achieve depth resolved spectroscopic analysis, we use the dual window method, which obtains simultaneously high spectral and depth resolution and yields access to the local oscillations. The results show highly statistically significant differences between the AOM-treated and control group samples. Further, the results suggest that fLCI may be used to detect the field effect of carcinogenesis, in addition to identifying specific areas where more advanced neoplastic development has occurred.

Paper Details

Date Published: 12 February 2011
PDF: 8 pages
Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 790712 (12 February 2011); doi: 10.1117/12.872929
Show Author Affiliations
Francisco E. Robles, Duke Univ. (United States)
Yizheng Zhu, Duke Univ. (United States)
Jin Lee, The Hamner Institutes for Health Sciences (United States)
Sheela Sharma, The Hamner Institutes for Health Sciences (United States)
Adam Wax, Duke Univ. (United States)


Published in SPIE Proceedings Vol. 7907:
Biomedical Applications of Light Scattering V
Adam P. Wax; Vadim Backman, Editor(s)

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