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Proceedings Paper

A comprehensive validation of patient-specific CFD simulations of cerebral aneurysm flow with virtual angiography
Author(s): Qi Sun; Alexandra Groth; Matthias Bertram; Olivier Brina; Vitor Mendes Pereira; Til Aach
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Paper Abstract

Recently, image-based computational fluid dynamic simulations (CFD) have been proposed to investigate the local hemodynamics inside human cerebral aneurysms. It is suggested that the knowledge of the computed three-dimensional flow fields can be used to assist clinical risk assessment and treatment decision making. However, the reliability of CFD for accurately representing the human cerebral blood flow is difficult to assess due to the impossibility of ground truth measurements. A recently proposed virtual angiography method has been used to indirectly validate CFD results by comparing virtually constructed and clinically acquired angiograms. However, the validations are not yet comprehensive as they lack either from patient-specific boundary conditions (BCs) required for CFD simulations or from quantitative comparison methods. In this work, a simulation pipeline is built up including image-based geometry reconstruction, CFD simulations solving the dynamics of blood flow and contrast agent (CA), and virtual angiogram generation. In contrast to previous studies, the patient-specific blood flow rates obtained by transcranial color coded Doppler (TCCD) ultrasound are used to impose CFD BCs. Quantitative measures are defined to thoroughly evaluate the correspondence between the clinically acquired and virtually constructed angiograms, and thus, the reliability of CFD simulations. Exemplarily, two patient cases are presented. Close similarities are found in terms of spatial and temporal variations of CA distribution between acquired and virtual angiograms. Besides, for both patient cases, discrepancies of less than 15% are found for the relative root mean square errors (rRMSE) in time intensity curve (TIC) comparisons from selected characteristic positions.

Paper Details

Date Published: 2 March 2011
PDF: 8 pages
Proc. SPIE 7964, Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling, 79642N (2 March 2011); doi: 10.1117/12.872865
Show Author Affiliations
Qi Sun, Philips Research Labs. (Germany)
RWTH Aachen Univ. (Germany)
Alexandra Groth, Philips Research Labs. (Germany)
Matthias Bertram, Philips Research Labs. (Germany)
Olivier Brina, Univ. Hospital of Geneva (Switzerland)
Vitor Mendes Pereira, Univ. Hospital of Geneva (Switzerland)
Til Aach, RWTH Aachen Univ. (Germany)


Published in SPIE Proceedings Vol. 7964:
Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling
Kenneth H. Wong; David R. Holmes, Editor(s)

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