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Proceedings Paper

VEGF-C as a survival factor for retinal pigment epithelial cells from photothermal stress
Author(s): Brent J. Lavey; Katharine E. Sheldon; Larry E. Estlack; Kurt J. Schuster; Michael D. Barnhart; Benjamin A. Rockwell
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Paper Abstract

Vascular endothelial growth factor (VEGF) is known for its role in neovascularization and cellular signaling pathways of sub-threshold retinal lesions. The objective of this study was to elucidate potential protection mechanisms to laser-induced heat stress utilizing an in vitro retinal model. The cell line was characterized to determine the relative abundance of VEGF-C protein. Cells, preconditioned via water bath and controls, were then exposed to 2 μm laser radiation to assess whether increases in protein production following preconditioning could confer any protection. There was no significant increase in threshold damage irradiance (ED50) in the preconditioned cells versus control.

Paper Details

Date Published: 17 February 2011
PDF: 7 pages
Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 78971L (17 February 2011); doi: 10.1117/12.872755
Show Author Affiliations
Brent J. Lavey, Air Force Research Lab. (United States)
Katharine E. Sheldon, Air Force Research Lab. (United States)
Larry E. Estlack, Conceptual MindWorks, Inc. (United States)
Kurt J. Schuster, TASC, Inc. (United States)
Michael D. Barnhart, U.S. Air Force Academy (United States)
Benjamin A. Rockwell, Air Force Research Lab. (United States)


Published in SPIE Proceedings Vol. 7897:
Optical Interactions with Tissue and Cells XXII
E. Duco Jansen; Robert J. Thomas, Editor(s)

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