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Proceedings Paper

A role for Nrf2 in UVA-mediated heme oxygenase induction and protection from membrane damage in human skin fibroblasts
Author(s): Haibin Li; Linhao Li; Linhong Deng; Gurinder Singh; Rex M. Tyrrell; J. Li Zhong
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Paper Abstract

Our previous study has shown that Ultraviolet-A (UVA) irradiation induces heme oxygenase 1 (HO-1) expression in cultured human primary skin fibroblasts FEK4. In the present study, we demonstrate a coordinated induction of HO-1 and NF-E2-related factor 2 (Nrf2) following UVA irradiation or hemin treatment. The induction of HO-1 by either UVA irradiation or hemin treatment was largely abolished by down-regulation of Nrf2 with its targeted short interfering RNA (siNrf2). The study further reveals that knockdown of Nrf2 protein increased UVA-induced cell death measured by MTS assay. These findings together indicate that Nrf2-mediated induction of HO-1 expression may provide a cytoprotection for human skin cells from oxidative damage.

Paper Details

Date Published: 9 November 2010
PDF: 7 pages
Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78450X (9 November 2010); doi: 10.1117/12.870980
Show Author Affiliations
Haibin Li, Chongqing Univ. (China)
Linhao Li, Chongqing Univ. (China)
Linhong Deng, Chongqing Univ. (China)
Gurinder Singh, Chongqing Univ. (China)
Rex M. Tyrrell, Univ. of Bath (United Kingdom)
J. Li Zhong, Chongqing Univ. (China)


Published in SPIE Proceedings Vol. 7845:
Optics in Health Care and Biomedical Optics IV
Qingming Luo; Ying Gu; Xingde Li, Editor(s)

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