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Proceedings Paper

Performance of hybrid system for fluorescence and micro-computed tomography in synchronous mode
Author(s): Xin Liu; Yi Zhang; Fei Liu; Xiaolian Guo; Xin Wang; Jing Bai
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Paper Abstract

Fluorescence diffuse optical tomography (FDOT) plays an important role in studying physiological and pathological processes of small animals in vivo. The low spatial resolution, however, limits the ability of FDOT in resolving the biodistributions of fluorescent markers. The anatomical information provided by X-ray computed tomography (CT) can be used to improve the image quality of FDOT. However, in most hybrid FDOT/CT systems, the projection data sets of optics and X-ray are acquired sequentially, which increases the acquisition time and bring in the unwanted soft tissue displacement. In this paper, we evaluate the performance of a synchronous FDOT/CT system, which allows for faster and concurrent imaging. Compared with previous FDOT/CT systems, the two subsystems (FDOT and CT) acquire projection images in synchronous mode, so the body position can keep consistent in the same projection data acquired by both subsystems. The experimental results of phantom and in vivo experiments suggest that the reconstruction quality of FDOT can be significantly improved when structural a priori information is utilized to constrain the reconstruction process. On the other hand, the synchronous FDOT/CT system decreases the imaging time.

Paper Details

Date Published: 9 November 2010
PDF: 6 pages
Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78450G (9 November 2010); doi: 10.1117/12.870001
Show Author Affiliations
Xin Liu, Tsinghua Univ. (China)
Yi Zhang, Tsinghua Univ. (China)
Fei Liu, Tsinghua Univ. (China)
Xiaolian Guo, Tsinghua Univ. (China)
Xin Wang, Tsinghua Univ. (China)
Jing Bai, Tsinghua Univ. (China)


Published in SPIE Proceedings Vol. 7845:
Optics in Health Care and Biomedical Optics IV
Qingming Luo; Ying Gu; Xingde Li, Editor(s)

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