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Proceedings Paper

Discriminant analysis for classification of colonic tissue autofluorescence spectra
Author(s): Lina Liu; Bingyang Liu; Weihua Li; Lisheng Lin; Buhong Li; Shusen Xie
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Paper Abstract

This study evaluates the potential of a discriminant analysis to classify colonic mucosa from autofluorescence spectral characteristics. With 337 nm excitation, the autofluorescence spectra of colonic tissues were measured using a FLS920 spectrofluorimeter. Principal component analysis (PCA) combined with Fisher's discriminant analysis was performed for tissue classification. As a result, the sensitivity and specificity of the discriminant analysis is 92.3% and 90.5%, respectively. The results suggest the relative concentrations of collagen and nicotinamide adenine dinucleotide (NADH) are the potential diagnostic biomarkers for colonic tissue classification using autofluorescence spectroscopy, and the discriminant analysis based on PCA is useful to differentiate adenocarcinoma from normal tissue.

Paper Details

Date Published: 8 November 2010
PDF: 6 pages
Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78450P (8 November 2010); doi: 10.1117/12.869965
Show Author Affiliations
Lina Liu, Fujian Normal Univ. (China)
Bingyang Liu, Fujian Normal Univ. (China)
Weihua Li, Fujian Provincial Hospital (China)
Lisheng Lin, Fujian Normal Univ. (China)
Buhong Li, Fujian Normal Univ. (China)
Shusen Xie, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 7845:
Optics in Health Care and Biomedical Optics IV
Qingming Luo; Ying Gu; Xingde Li, Editor(s)

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